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Melano CC Anti-Spot White Lotion Rich

Release Date
2018.9.2 Repackaged in March 2021.
170ml Bottle / Refill
Melano CC
ROHTO Pharmaceutical Co.
Product Type
¥900 / ¥800

Quasi-Drug (医薬部外品) Melano CC Anti-Spot White Lotion Rich (also known as Melano CC Vitamin C Whitening Lotion Rich) is a hydrating Japanese watery lotion that targets excess pigmentation.

The moisture-replenishing toner is medicated with vitamin C derivative and Dipotassium Glycyrrhizate to treat and prevent dark spots and freckles while reducing inflammation. Alpinia White, lemon extract, and grapefruit extract boost skin’s clarity and hydration.

The lotion has a rich texture that penetrates into the deeper layers of the skin to replenish moisture and prevent excess pigmentation.

Refreshing Yuzu Fragrance


Skin Type(s):   
Beauty Concern(s):   


Active(s): 3-O-Ethyl Ascorbic Acid (Ethyl Ascorbic Acid) & Dipotassium Glycyrrhizate.

Other Ingredients: Water,, butylene glycol,, glycerin,, dipropylene glycol,, ascorbic acid,, citrus grandis (grapefruit) fruit extract,, citrus medica limonum (lemon) fruit extract,, alpinia katsumadai seed extract (Alpinia White),, do.not.copy,, PPG-6-decyltetradeceth-30,, methylparaben,, sodium citrate,, citric acid,, xanthan gum,, disodium EDTA,, fragrance.


メラノCC 薬用しみ対策美白化粧水 しっとりタイプ」の有効成分:3-O-エチルアスコルビン酸(高浸透ビタミンC誘導体)、グリチルリチン酸ジカリウム


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5 Comments on Melano CC Anti-Spot White Lotion Rich

  1. Excuse me. Is it fine to use it together with Melano cc essence? I’m thinking that it may be too much vitamin c for the skin that it may cause some irritations.

  2. I would have really wanted to try this had it not been the grapefruit and lemon extracts. They’re known the cause phototoxic reactions on skin and I would caution anyone to use it during the day. Furocoumarin derivatives in the extracts can react with UV light causing the release of toxins on skin. Such a shame because the rest of the ingredients looks very promising…..

    • Phototoxicity refers to pure, undiluted ingredients. When used as part of many other ingredients, they are perfectly safe. Steam-distillation also removes the components that cause phototoxicity, making them safe to use in the sun even if they’re undiluted.

      Also “phototoxicity” just means that the essential oil or extract may increase the likelihood of skin sensitivity if exposed to UV rays. It doesn’t release toxins— it absorbs UV photons, stores them, and then release them in a burst on to the skin.

      • Upon more research I was wrong about it releasing toxins. It seems two types of toxic reactions occur: one is oxygen independent, in which the ultraviolet-activated furocoumarins bind to RNA and nuclear DNA; another is oxygen dependent, where induced furocoumarins cause cell membrane damage and edema. And research seems to suggest that when used in a low concentration in formulations it shouldn’t cause phototoxicity if a sunscreen is applied over the product.

        But disregarding the phototoxicity potential, lemon peel extracts still contain up to 70% d-limonene. And limonene is known to cause mild skin irritation, as it dissolves protective skin oils. ‘It was also proved that d-limonene, can initiate autophagic processes at concentration 0.02% v/v. This concentration is responsible for initiation of multiple death pathways in human neuroblastoma cells, resulting in cytoskeletal alteration, caspase-3 activation, DNA fragmenta- tion, mitochondrial dysfunction, plasma membrane damage, and cleavage of pro-survival protein.’

        In my opinion, despite lemon and grapefruit peel extract have great antioxidant activity, the side effects just don’t justify its use when there are already so many great antioxidants in this product. I understand it’s also included as a marketing campaign since a lot of vitamin C products are marketed with citrus. However as the 3rd and 4th ingredient on the ingredients list I still worry about its potential to cause more harm than good.

        • The keyword here is “up to” — this doesn’t contain limonene as an ingredient, which would be listed separately.

          Personally, I’m not concerned about citrus extracts in skincare products at all. It’s a non-issue if the skin isn’t sensitive to them. There’re, of course, plenty of other options you rather steer clear of them.

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